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485
485Jul 14, 20261h 21m

The New Science of Cancer

with Siddhartha Mukherjee

Sam Harris speaks with Siddhartha Mukherjee about the science of cancer. They discuss the updated edition of The Emperor of All Maladies , whether cancer is one disease or many, why prevention is so hard, inflammation and air pollution as carcinogens, the myth that cell phones cause cancer, liquid biopsies and Bayesian reasoning, immunotherapy and CAR T cells, drug pricing, the promise of AI in drug discovery, the state of American medical science, and other topics. Siddhartha Mukherjee is the author of The Song of the Cell ; The Gene: An Intimate History , a #1 New York Times bestseller; and The Laws of Medicine . He is a Rhodes scholar, an associate professor of medicine at Columbia University, and a cancer physician and researcher. He has published articles in many journals, including Nature , Cell , The New York Times Magazine , The New Yorker , and others. Website: SiddharthaMukherjee.com X: @DrSidMukherjee Share this episode: https://www.samharris.org/podcasts/making-sense-episodes/485-the-new-science-of-cancer

484
484Jul 8, 20261h 37m

Artificial Intimacy

with Paul Bloom

Sam Harris speaks with Paul Bloom about our relationships with AI and the future of human connection. They discuss the surprising pace of AI progress, AI companions as a remedy for loneliness, the importance of mattering to other people, digitally resurrecting the dead, whether AI can be conscious, the moral failings of artists, what science actually knows about parenting, the ethics of apology, why late converts from Trump provoke outrage, and other topics. Paul Bloom is Professor of Psychology at the University of Toronto and Brooks and Suzanne Ragen Professor Emeritus of Psychology at Yale University. Paul Bloom studies how children and adults make sense of the world, with special focus on pleasure, morality, religion, fiction, and art. He has won numerous awards for his research and teaching. He is past-president of the Society for Philosophy and Psychology and co-editor of Behavioral and Brain Sciences. He has written for scientific journals such as Nature and Science , and for popular outlets such as The New York Times , The Guardian , The New Yorker , and The Atlantic Monthly . He is the author of seven books, including his latest Psych: The Story of the Human Mind . You can subscribe to his Substack, Small Potatoes. Website: paulbloom.net X: @paulbloomatyale Share this episode: https://www.samharris.org/podcasts/making-sense-episodes/484-artificial-intimacy

483
483Jul 1, 20261h 25m

The Knots We Tie Ourselves Into

with Alain de Botton

Sam Harris speaks with Alain de Botton about the psychology of unhappiness, the secular world's discomfort with ecstasy and ritual, psychedelics as a tool for self-discovery, Freud's legacy, AI as the ultimate mirror, the case against meritocracy, the cancel culture purity trap, the psychological meaning of death, and other topics. Alain de Botton is a writer, psychotherapist, and founder of The School of Life. He is interested in art, ideas, and the need for emotional education to help us manage relationships and make better choices. Websites: alaindebotton.com , theschooloflife.com Share this episode: https://www.samharris.org/podcasts/making-sense-episodes/483-the-knots-we-tie-ourselves-into

482
482Jun 25, 20261h 07mMore From Sam

More From Sam: The Iran Deal, College in the AI Age, Mamdani’s DSA, and More

In this latest episode of the More From Sam series, Sam and Jaron talk about current events. They discuss topics from Making Sense Community, including one-world government, the value of a degree as AI reshapes careers, and factory farming ethics, along with Mamdani’s DSA-aligned candidates, Trump’s humiliating capitulation in the Iran deal, the Tulsi Gabbard guru story, and other topics. Share this episode: https://www.samharris.org/podcasts/making-sense-episodes/482-more-from-sam-the-iran-deal-college-in-the-ai-age-mamdanis-dsa-and-more

481
481Jun 17, 202654:31

Sam Harris Receives the 2026 Richard Dawkins Award

Richard Dawkins presents Sam Harris with the 2026 Richard Dawkins Award at a live Center for Inquiry event. After the tribute, the two friends discuss consciousness and epiphenomenalism, AI and the Turing test, the scientific basis of morality, the failures of democracy and Trump’s corruption, the role of philosophy, changing deeply held beliefs, Sam’s path to meditation, the legacy of Christopher Hitchens, and other topics. Share this episode: https://www.samharris.org/podcasts/making-sense-episodes/481-sam-harris-receives-the-2026-richard-dawkins-award

480
480Jun 12, 20261h 03m

The Economics of Everything

Sam Harris speaks with economist and Substack writer Noah Smith about the U.S. national debt, wealth inequality, and the economic consequences of AI. They discuss the mechanics of debt and inflation, the case for fiscal austerity, why the U.S. squandered low interest rates, modern monetary theory, how AI may restructure labor and ownership, the anti-billionaire politics of the American left, the degrowth movement and its failures, demographic decline and fertility trends, the role of smartphones in eroding democratic culture, and other topics. Noah Smith is an economics blogger and former finance professor. He writes a Substack called Noahpinion. Website: http://noahpinion.blog X: @noahpinion Share this episode: https://www.samharris.org/podcasts/making-sense-episodes/480-the-economics-of-everything

479
479Jun 4, 202642:59

When Robots Take Over

with Vinod Khosla

Sam Harris speaks with Vinod Khosla about AI, economic disruption, and political risk. They discuss the prospect of mass job displacement, a trillion-dollar policy framework to redistribute AI's gains, the failure of the California wealth tax, the corporate capitulation to Trump, Elon Musk's embrace of white nationalist rhetoric, US-China competition, semiconductor dependence, and other topics. Vinod Khosla is an entrepreneur, investor, and technology fan. He is the founder of Khosla Ventures, focused on impactful technology investments in software, AI, robotics, 3D printing, healthcare, and more​. Mr. Khosla was a co-founder of Daisy Systems and founding CEO of Sun Microsystems, where he pioneered open systems and commercial RISC processors. One of Mr. Khosla’s greatest passions is being a mentor to entrepreneurs, assisting entrepreneurs, and helping them build technology-based businesses. ​Mr. Khosla is driven by the desire to make a positive impact through technology to reinvent societal infrastructure and multiply resources. He is also passionate about Social Entrepreneurship. Vinod holds a Bachelor of Technology in Electrical Engineering from IIT, New Delhi, a Master's in Biomedical Engineering from Carnegie Mellon University, and an MBA from the Stanford Graduate School of Business. X: @vkhosla Share this episode: https://www.samharris.org/podcasts/making-sense-episodes/479-when-robots-take-over

478
478May 29, 20261h 29m

The Psychedelic Mind

with Robin Carhart-Harris

Sam Harris speaks with Robin Carhart-Harris about psychedelic research and its therapeutic potential. They discuss the current state of the field, the FDA denial of MDMA-assisted therapy for PTSD, the critical role of set and setting, risks for vulnerable populations, the REBUS model of how psychedelics work on the brain, the default mode network and ego dissolution, microdosing, the neuroscience of consciousness, DMT entities, and other topics. Dr Carhart-Harris moved to Imperial College London in 2008 after obtaining a PhD in Psychopharmacology from the University of Bristol. He has designed human brain imaging studies with LSD, psilocybin, MDMA, and DMT, and several clinical trials of psilocybin therapy for severe mental illnesses, including 3 key trials in depression plus 2 further trials in anorexia and fibromyalgia syndrome. Dr Carhart-Harris founded the Centre for Psychedelic Research at Imperial College London in April 2019, the first of its kind in the world. In 2020, he was named among the top 31 medical scientists by The Times newspaper. Dr Carhart-Harris became the inaugural Ralph Metzner Distinguished Professor of Neurology and Psychiatry at the University of California, San Francisco in 2021, and in the same year, was listed in TIME magazine’s ‘100 Next’ - a list of emerging leaders from around the world who are shaping the future. Website: carhartharrislab.com X: @RCarhartHarris Share this episode: https://www.samharris.org/podcasts/making-sense-episodes/478-the-psychedelic-mind

477
477May 26, 20261h 08mMore From Sam

More From Sam: Iran's Unraveling, The Gaza Information War, AI-Generated Music, and More

Warning: This episode contains graphic descriptions of violence against civilians during the October 7 attacks (33:49 - 34:35 in audio, 39:13 - 40:09 in video). Listener discretion is advised. In this latest episode of the More From Sam series, Sam and Jaron talk about current events. They discuss the Trump administration's bungled Iran campaign, the information war surrounding Gaza and October 7, Nicholas Kristof's disputed New York Times report on Israeli prisoner abuse, Sam's controversial take on AI-generated music, OpenAI solving a decades-old math problem, the ethics of concealing GLP-1 use, and other topics. Share this episode: https://www.samharris.org/podcasts/making-sense-episodes/477-more-from-sam-irans-unraveling-the-gaza-information-war-ai-generated-music-and-more

476
476May 20, 20261h 20m

The Bittersweet Age

with Susan Cain

Sam Harris speaks with Susan Cain about writing, creativity, and what AI means for human culture. They discuss the future of books and reading, the tells AI inherits from good writers, why the advent of AI may spark a revival of the humanities, following your bliss, the ethics of curing sadness, the therapeutic potential of psychedelics, and other topics. Susan Cain is the author of the global sensation and #1 New York Times Bestseller Quiet , and the instant #1 New York Times bestseller Bittersweet , an Oprah Book Club Selection. Susan's new children's book Lucky & Norman will be published on June 2, 2026. She has spent the last twenty years exploring a particular realm of human nature: the quiet, the sensitive, the thoughtful, the bittersweet. It has always seemed clear to her—and to her millions of readers—that this way of being can lead to a richer, deeper form of happiness. Susan is the host of The Quiet Life Substack community, and her newsletter is read by people in all 193 countries and all 50 American states. Join her at TheQuietLife.net ! Website: https://thequietlife.net/welcome X: @susancain Instagram: @susancainauthor Share this episode: https://www.samharris.org/podcasts/making-sense-episodes/476-the-bittersweet-age

475
475May 12, 20261h 18m

The Hard Problem of Consciousness

with Michael Pollan

Sam Harris speaks with Michael Pollan about consciousness, the mind, and the self. They discuss Pollan’s new book, the relationship between consciousness and intelligence, whether consciousness is a product of evolution, the role of psychedelics in consciousness research, AI and the question of machine consciousness, the illusion of the self, and other topics. Michael Pollan is the John S. and James L. Knight Professor of Journalism at UC Berkeley and the author of eight books, including How to Change Your Mind , his 2018 account of the renaissance of scientific research into psychedelics. In July 2022, Netflix released a docuseries based on How to Change Your Mind , exploring the history and uses of substances including LSD, psilocybin, MDMA, and mescaline. His latest, A World Appears: A Journey into Consciousness , explores consciousness—what it is, who has it, and why. Website: https://michaelpollan.com/ X: @michaelpollan Share this episode: https://www.samharris.org/podcasts/making-sense-episodes/475-the-hard-problem-of-consciousness

474
474May 7, 20261h 02mMore From Sam

More From Sam: Hasan Piker, Islamism, Making Sense Community, and More

In this latest episode of the More From Sam series, Sam and Jaron talk about current events. They discuss the launch of Making Sense Community, Sam’s Ben Shapiro conversation, the New York Times ’s embrace of Hasan Piker, Zohran Mamdani’s approach to Islamism, the misuse of the word “genocide,” AI-driven job displacement, and other topics. Share this episode: https://www.samharris.org/podcasts/making-sense-episodes/474-hasan-piker-islamism-making-sense-community-and-more

473
473Apr 29, 20261h 15m

Money, Power, and Moral Failure

with Lloyd Blankfein

Sam Harris speaks with Lloyd Blankfein about finance, politics, and the state of American society. They discuss Blankfein’s memoir, Goldman Sachs and its role as a market maker, the 2007-2008 financial crisis, the AI investment bubble, wealth inequality and the rise of trillionaires, the crisis of antisemitism on the left and right, Trump-era corruption and the post-truth political environment, the national debt, and other topics. Lloyd Blankfein was chairman and CEO of Goldman Sachs from 2006 to 2018. Share this episode: https://www.samharris.org/podcasts/making-sense-episodes/473-money-power-and-moral-failure

472
472Apr 24, 20261h 01m

Strange Days on the Right

with Ben Shapiro

Sam Harris speaks with Ben Shapiro about their pre-election debate and the fractures on the right. They discuss Trump's second term surprises, familial corruption, tariff policy, the ideological world of Tucker Carlson, the spread of conspiracism on the right, antisemitism as the ur-conspiracy theory, JD Vance's political calculations, the future of Israel and the Palestinian question, and other topics. Ben Shapiro is Co-Founder of The Daily Wire and host of The Ben Shapiro Show, which has ranked among the top ten podcasts globally since 2018 and is the leading conservative podcast in the United States. Shapiro is the author of 17 books, including his latest New York Times bestseller, Lions and Scavengers: The True Story of America (and Her Critics) . At age 17, Shapiro became the youngest nationally syndicated columnist in the U.S. when hired by Creators Syndicate. Shapiro graduated summa cum laude with a B.A. in Political Science from UCLA in 2004 and earned his J.D. from Harvard Law School in 2007. In 2015, Shapiro and Jeremy Boreing launched The Daily Wire, which rapidly rose to become one of the most influential news outlets in America. Website: https://www.dailywire.com X: @Benshapiro Share this episode: https://www.samharris.org/podcasts/making-sense-episodes/472-strange-days-on-the-right

471
471Apr 16, 20261h 05m

The End of History, Revisited

with Francis Fukuyama

Sam Harris speaks with Francis Fukuyama about liberal democracy, American politics, and global order. They discuss the misunderstood thesis of "The End of History," how conservatism has mutated into ethno-nationalism, the self-defeating extremes of both identity politics and neoliberalism, the damage of Trump's second term, the war in Iran, the future of Israel, antisemitism on the left and right, and other topics. Francis Fukuyama is the Olivier Nomellini Senior Fellow at Stanford University's Freeman Spogli Institute for International Studies and Director of Stanford's Ford Dorsey Master's in International Policy. One of the most influential political thinkers of his generation, he is best known for his 1992 book The End of History and the Last Man . His forthcoming memoir is In the Realm of the Last Man . Dr. Fukuyama has held distinguished appointments at Johns Hopkins, George Mason University, the RAND Corporation, and the U.S. Department of State's Policy Planning Staff. His articles can be read at Persuasion , and his podcast is Frankly Fukuyama. Website: francisfukuyama.com X: @FukuyamaFrancis Share this episode: https://www.samharris.org/podcasts/making-sense-episodes/471-the-end-of-history-revisited

470
470Apr 13, 20261h 16m

Democrats at a Crossroads

with Rahm Emanuel

Sam Harris speaks with Rahm Emanuel about American politics, the state of the Democratic Party, and the 2028 presidential race. They discuss Emanuel’s possible presidential run, identity politics and the left’s cultural cul-de-sac, the Mississippi reading miracle, antisemitism on the left and right, the Gaza war, Netanyahu’s failures, U.S. policy toward China, wealth inequality, and other topics. Rahm I. Emanuel most recently served as the United States Ambassador to Japan. Previously, he was the 55th Mayor of the City of Chicago, a position he held until May 2019. Prior to becoming Mayor, from November 2008 until October 2010, Emanuel served as President Barack Obama’s Chief of Staff. Before serving as Chief of Staff, Emanuel was elected four times as a Member of the U.S. House of Representatives from Illinois’s 5th Congressional District (2002-2008). From 1993 to 1998, Ambassador Emanuel was a key member of President Bill Clinton’s administration, rising to serve as Senior Advisor to the President for Policy and Politics. X: @RahmEmanuel Share this episode: https://www.samharris.org/podcasts/making-sense-episodes/470-democrats-at-a-crossroads

469
469Apr 10, 20261h 49m

Escaping an Anti-Human Future

with Tristan Harris

Sam Harris speaks with Tristan Harris about the dangers of AI and the race to build it. They discuss the new documentary The AI Doc: Or How I Became an Apocaloptimist , the lessons of The Social Dilemma , the arms race dynamics between AI labs, the "intelligence curse" and its implications for human political power, the psychology of tech CEOs indifferent to extinction risk, the possibilities of US-China coordination on AI safety, and other topics. Tristan Harris , described by The Atlantic as “the closest thing Silicon Valley has to a conscience,” is a technology ethicist and co-founder of the Center for Humane Technology, a nonprofit dedicated to aligning technology with humanity’s best interests. Tristan gained international recognition when he was featured in the Emmy-winning Netflix documentary, The Social Dilemma , seen by over 150 million people in 190 countries and 30 languages. Named to the TIME100 AI list in 2023, Tristan is “a tech leader committed to ensuring that we get this generation of AI right, because we simply can’t afford to get it wrong.” Most recently, Tristan is featured in The AI Doc: Or How I Became an Apocaloptimist , a new documentary from Focus Features in theaters March 27, 2026. Website: humanetech.com X: @tristanharris Share this episode: https://www.samharris.org/podcasts/making-sense-episodes/469-escaping-an-anti-human-future

468
468Apr 7, 20261h 24mMore From Sam

More From Sam: Gratitude, Bad Conversations, Conspiracy Addiction, Waffle House Teleportation, and More

In this latest episode of the More From Sam series, Sam and Jaron talk about current events. They discuss how to cultivate gratitude and navigate anxiety in uncertain times, the role of mindfulness in coping with AI-driven job displacement, the slowing of religious decline in America, a FEMA official's claim that he teleported to a Waffle House, the irresponsibility of conspiracy-fueled podcasting, Sam on which conversations are worth having, and other topics. Share this episode: https://www.samharris.org/podcasts/making-sense-episodes/468-more-from-sam-gratitude-bad-conversations-conspiracy-addiction-waffle-house-teleportation-and-more

467
467Mar 30, 20261h 43m

EA, AI, and the End of Work

with William MacAskill

Sam Harris speaks with William MacAskill about effective altruism, AI, and the future of humanity. They discuss the post-FTX recovery of the EA movement, global health and pandemic preparedness, the limits of quantifiable ethics, the intelligence explosion, risks of concentrated AI power, what a post-scarcity world might look like, and other topics. Will MacAskill is an associate professor of moral philosophy at Oxford University, and author of Doing Good Better , Moral Uncertainty and What We Owe The Future . He cofounded the nonprofits 80,000 Hours, Centre for Effective Altruism, and Giving What We Can, and helped to launch the effective altruism movement, which encourages people to use their time and money to support the projects that are most effectively making the world a better place. Website: https://www.givingwhatwecan.org/ X: @willmacaskill Share this episode: https://www.samharris.org/podcasts/making-sense-episodes/467-ea-ai-and-the-end-of-work

466
466Mar 24, 20261h 06m

What Is Technology Doing to Us?

with Nicholas Christakis

Sam Harris speaks with Nicholas Christakis about technology, society, and human nature. They discuss the harms of modern communication technology, polarization and anomie, how AI agents can improve human cooperation, the social implications of humanoid robots, Christakis’s experience at the center of the woke moral panic at Yale, the Trump administration’s assault on American universities and science, the collapse of public trust in institutions, and other topics. Nicholas A. Christakis , MD, PhD, MPH, is the Sterling Professor of Social and Natural Science at Yale University. His work is in the fields of network science and biosocial science. He directs the Human Nature Lab and is the Co-Director of the Yale Institute for Network Science. He was elected to the National Academy of Medicine in 2006; the American Association for the Advancement of Science in 2010; the American Academy of Arts and Sciences in 2017; and the National Academy of Sciences in 2024. Website: https://humannaturelab.net/ YouTube: https://www.youtube.com/@NAChristakis X: @NAChristakis Share this episode: https://www.samharris.org/podcasts/making-sense-episodes/466-what-is-technology-doing-to-us

465
465Mar 18, 20261h 29mMore From Sam

More From Sam: Iran, Jihadism, Conspiracism, AI Disruption, the Manosphere, and More

In this latest episode of the More From Sam series, Sam and Jaron talk about current events. They discuss the Iran war and the Trump administration’s shambolic messaging, antisemitism and moral confusion on the left and right, the spread of conspiracism, finding contentment in uncertain times, AI’s looming disruption of white-collar work, wealth inequality and the ultra-rich’s failures of philanthropy, Louis Theroux’s documentary on the manosphere, and other topics. Share this episode: https://www.samharris.org/podcasts/making-sense-episodes/465-more-from-sam-iran-jihadism-conspiracism-ai-disruption-the-manosphere-and-more

464
464Mar 16, 20261h 22m

The Politics of Pragmatism and the Future of California

with Matt Mahan

Sam Harris speaks with Matt Mahan, mayor of San Jose and Democratic candidate for governor of California, about governance, pragmatism, and California's policy failures. They discuss the dysfunction of progressive governance, the homelessness crisis and what San Jose has done to reduce it, the proposed wealth tax and its likely backfire, why California can't build housing affordably, rent control, mandatory psychiatric holds, the influence of special interests in Sacramento, and other topics. Matt Mahan is the Mayor of San Jose and a candidate for Governor of California. Raised in Watsonville and a Harvard graduate, he began his career in the Peace Corps before teaching on San Jose's East Side. He went on to lead two civic tech startups, Causes and Brigade, focused on civic engagement and nonprofit support. Elected Mayor in 2022, Mahan has made homelessness and public safety his central priorities. Under his leadership, San Jose reduced unsheltered homelessness by nearly a third through the largest expansion of emergency shelter on the West Coast, and earned recognition as the safest big city in America. He has also worked to accelerate housing development by cutting permitting costs and timelines, and took on utility companies to lower energy costs for residents. In 2024, he was re-elected with 87% of the vote and helped lead the passage of Proposition 36, a statewide ballot measure enabling mandated treatment for repeat offenders in cases involving retail theft, homelessness, and addiction. He announced his run for California governor in January 2026. Website: https://mahanforcalifornia.com X: https://x.com/MattMahanSJ Share this episode: https://www.samharris.org/podcasts/making-sense-episodes/464-the-politics-of-pragmatism-and-the-future-of-california

463
463Mar 11, 20261h 22m

Privatizing the Apocalypse

with Rob Reid

Sam Harris speaks with Rob Reid about biosecurity, pandemic risk, and the alarming fragility of our defenses against biological catastrophe. They discuss the controversial USAID program DEEP VZN, the dangers of gain-of-function research, open science norms that could arm bad actors, the role of AI in accelerating bioweapon development, biosurveillance tools, lone wolf bioterrorists, chaos agents, and other topics. Rob Reid is a venture capitalist, sci-fi author, science writer, and podcaster; he was also a long-time tech entrepreneur. Rob is the Managing Director at Resilience Reserve , a venture fund he runs with Chris Anderson of the TED Conference. Resilience backs companies that are making the world more resilient in some important way. Rob’s After On podcast features conversations with world-class thinkers, founders, and scientists on subjects including synthetic biology, generative and super AI, neuroscience, astrophysics, and oceanography. His science fiction novels include the New York Times bestseller Year Zero and After On . As an entrepreneur, Rob founded and ran Listen.com, which created the Rhapsody music service. He speaks solid Arabic with a thick Egyptian accent. Website: https://after-on.com/ X: https://x.com/Rob_Reid Share this episode: https://www.samharris.org/podcasts/making-sense-episodes/463-privatizing-the-apocalypse

462
462Mar 6, 202659:56More From Sam

More From Sam: The Iran War, American Amorality, Addressing Hopelessness, Tucker, and More

In this latest episode of the More From Sam series, Sam and Jaron talk about current events. They discuss whether the U.S. was right to take military action against Iran, the new era of American amorality, antisemitism on the left and right, Tucker Carlson's provocative interview with Mike Huckabee, navigating feelings of hopelessness and dread, the dangers and promise of psychedelics, the corrosive effects of social media on culture and politics, and other topics. Share this episode: https://www.samharris.org/podcasts/making-sense-episodes/462-more-from-sam-the-iran-war-american-amorality-tucker-carlson-and-more

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